diff --git a/Packages/src/Editor/UIParticleEditor.cs b/Packages/src/Editor/UIParticleEditor.cs
index 801bebe..4f58152 100644
--- a/Packages/src/Editor/UIParticleEditor.cs
+++ b/Packages/src/Editor/UIParticleEditor.cs
@@ -82,6 +82,18 @@ namespace Coffee.UIExtensions
             "_ColorMask"
         };
 
+        /// <summary>
+        /// ドメインリロード無効化対応：静的キャッシュをクリア
+        /// </summary>
+        [InitializeOnLoadMethod]
+        private static void OnDomainReload()
+        {
+            s_Shaders.Clear();
+#if UNITY_2018 || UNITY_2019
+            s_Streams.Clear();
+#endif
+        }
+
         //################################
         // Public/Protected Members.
         //################################
diff --git a/Packages/src/Runtime/Internal/ProjectSettings/PreloadedProjectSettings.cs b/Packages/src/Runtime/Internal/ProjectSettings/PreloadedProjectSettings.cs
index 36e38ed..d282ae2 100644
--- a/Packages/src/Runtime/Internal/ProjectSettings/PreloadedProjectSettings.cs
+++ b/Packages/src/Runtime/Internal/ProjectSettings/PreloadedProjectSettings.cs
@@ -195,6 +195,13 @@ namespace Coffee.UIParticleInternal
         private static T s_Instance;
 
 #if UNITY_EDITOR
+#if UNITY_2019_3_OR_NEWER
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void OnDomainReload()
+        {
+            s_Instance = null;
+        }
+#endif
         private string _jsonText;
 
         public static bool hasInstance => s_Instance != null;
diff --git a/Packages/src/Runtime/Internal/Utilities/UIExtraCallbacks.cs b/Packages/src/Runtime/Internal/Utilities/UIExtraCallbacks.cs
index 758536a..89d1ca2 100755
--- a/Packages/src/Runtime/Internal/Utilities/UIExtraCallbacks.cs
+++ b/Packages/src/Runtime/Internal/Utilities/UIExtraCallbacks.cs
@@ -82,14 +82,22 @@ namespace Coffee.UIParticleInternal
                 message: "InitializeAfterCanvasRebuild");
         }
 
-#if UNITY_EDITOR
+#if UNITY_EDITOR && UNITY_2019_3_OR_NEWER
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+#elif UNITY_EDITOR
         [InitializeOnLoadMethod]
-#endif
+#else
         [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.BeforeSceneLoad)]
+#endif
         private static void InitializeOnLoad()
         {
             Canvas.willRenderCanvases -= OnAfterCanvasRebuild;
             s_IsInitializedAfterCanvasRebuild = false;
+            s_AfterCanvasRebuildAction.Clear();
+            s_LateAfterCanvasRebuildAction.Clear();
+            s_BeforeCanvasRebuildAction.Clear();
+            s_OnScreenSizeChangedAction.Clear();
+            s_LastScreenSize = default;
         }
 
         /// <summary>
diff --git a/Packages/src/Runtime/UIParticleUpdater.cs b/Packages/src/Runtime/UIParticleUpdater.cs
index d82f485..2495c85 100644
--- a/Packages/src/Runtime/UIParticleUpdater.cs
+++ b/Packages/src/Runtime/UIParticleUpdater.cs
@@ -39,6 +39,17 @@ namespace Coffee.UIExtensions
         }
 
 #if UNITY_EDITOR
+#if UNITY_2019_3_OR_NEWER
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void OnDomainReload()
+        {
+            s_ActiveParticles.Clear();
+            s_ActiveAttractors.Clear();
+            s_UpdatedGroupIds.Clear();
+            s_FrameCount = 0;
+        }
+#endif
+
         [InitializeOnLoadMethod]
         private static void InitializeOnLoad()
         {